| First Author | Easton AC | Year | 2013 |
| Journal | Behav Brain Res | Volume | 252 |
| Pages | 72-6 | PubMed ID | 23732653 |
| Mgi Jnum | J:199094 | Mgi Id | MGI:5500840 |
| Doi | 10.1016/j.bbr.2013.05.045 | Citation | Easton AC, et al. (2013) alphaCaMKII autophosphorylation controls the establishment of alcohol-induced conditioned place preference in mice. Behav Brain Res 252C:72-76 |
| abstractText | The autophosphorylation of alpha Ca2+/calmodulin dependent protein kinase II (alphaCaMKII) is important for memory formation and is becoming increasingly implicated in the development of drug addiction. Previous work suggests that alphaCaMKII acts via the monoaminergic systems to facilitate the establishment of alcohol drinking behaviour. The present study aims to investigate whether alphaCaMKII autophosphorylation deficient alphaCaMKIIT286A mice show a difference in the rewarding properties of alcohol (2g/kg, i.p.), as measured by conditioned place preference (CPP). We found that alcohol-induced CPP could be established at an accelerated rate in alphaCaMKIIT286A compared to wild type (WT) mice. Hyperactivity/hyper-arousal induced by the test environment was normalised by alcohol in the alphaCaMKIIT286A, but not WT mice. This effect could be conditioned to the test environment and may suggest enhanced negative reinforcing action of alcohol in alphaCaMKII autophosphorylation deficient mice. |
