| First Author | Glazewski S | Year | 2000 |
| Journal | Nat Neurosci | Volume | 3 |
| Issue | 9 | Pages | 911-8 |
| PubMed ID | 10966622 | Mgi Jnum | J:64187 |
| Mgi Id | MGI:1888839 | Doi | 10.1038/78820 |
| Citation | Glazewski S, et al. (2000) The role of alpha-CaMKII autophosphorylation in neocortical experience-dependent plasticity. Nat Neurosci 3(9):911-8 |
| abstractText | Calcium/calmodulin kinase type II (CaMKII) is a major postsynaptic density protein. CaMKII is postulated to act as a 'molecular switch', which, when triggered by a transient rise in calcium influx, becomes active for prolonged periods because of its ability to autophosphorylate. We studied experience-dependent plasticity in the barrel cortex of mice carrying a point mutation of the alpha-CaMKII gene (T286A), which abolishes this enzyme's ability to autophosphorylate. Plasticity was prevented in adult and adolescent mice homozygous for the mutation, but was normal in heterozygotes and wild-type littermates. These results provide evidence that the molecular switch hypothesis is valid for neocortical experience-dependent plasticity. |
