| First Author | Vicencio-Jimenez S | Year | 2023 |
| Journal | Brain Sci | Volume | 13 |
| Issue | 5 | PubMed ID | 37239266 |
| Mgi Jnum | J:355549 | Mgi Id | MGI:7715048 |
| Doi | 10.3390/brainsci13050794 | Citation | Vicencio-Jimenez S, et al. (2023) Maintained Spatial Learning and Memory Functions in Middle-Aged alpha9 Nicotinic Receptor Subunit Knock-Out Mice. Brain Sci 13(5) |
| abstractText | Age-related hearing loss is linked to cognitive impairment, but the mechanisms that relate to these conditions remain unclear. Evidence shows that the activation of medial olivocochlear (MOC) neurons delays cochlear aging and hearing loss. Consequently, the loss of MOC function may be related to cognitive impairment. The alpha9/alpha10 nicotinic receptor is the main target of cholinergic synapses between the MOC neurons and cochlear outer hair cells. Here, we explored spatial learning and memory performance in middle-aged wild-type (WT) and alpha9-nAChR subunit knock-out (KO) mice using the Barnes maze and measured auditory brainstem response (ABR) thresholds and the number of cochlear hair cells as a proxy of cochlear aging. Our results show non-significant spatial learning differences between WT and KO mice, but KO mice had a trend of increased latency to enter the escape box and freezing time. To test a possible reactivity to the escape box, we evaluated the novelty-induced behavior using an open field and found a tendency towards more freezing time in KO mice. There were no differences in memory, ABR threshold, or the number of cochlear hair cells. We suggest that the lack of alpha9-nAChR subunit alters novelty-induced behavior, but not spatial learning in middle-aged mice, by a non-cochlear mechanism. |
