| First Author | Wangdi T | Year | 2010 |
| Journal | Infect Immun | Volume | 78 |
| Issue | 11 | Pages | 4744-53 |
| PubMed ID | 20823203 | Mgi Jnum | J:165027 |
| Mgi Id | MGI:4836096 | Doi | 10.1128/IAI.00744-10 |
| Citation | Wangdi T, et al. (2010) In vivo discrimination of type 3 secretion system-positive and -negative Pseudomonas aeruginosa via a caspase-1-dependent pathway. Infect Immun 78(11):4744-53 |
| abstractText | Microbe-associated molecular patterns are recognized by Toll-like receptors of the innate immune system. This recognition enables a rapid response to potential pathogens but does not clearly provide a way for the innate immune system to discriminate between virulent and avirulent microbes. We find that pulmonary infection of mice with type 3 translocation-competent Pseudomonas aeruginosa triggers a rapid inflammatory response, while infection with isogenic translocation-deficient mutants does not. Discrimination between translocon-positive and -negative bacteria requires caspase-1 activity in bone marrow-derived cells and interleukin-1 receptor signaling. Thus, the activation of caspase-1 by bacteria expressing type 3 secretion systems allows for rapid recognition of bacteria expressing conserved functions associated with virulence. |
