| First Author | Gu Y | Year | 1997 |
| Journal | Science | Volume | 275 |
| Issue | 5297 | Pages | 206-9 |
| PubMed ID | 8999548 | Mgi Jnum | J:298991 |
| Mgi Id | MGI:6489819 | Doi | 10.1126/science.275.5297.206 |
| Citation | Gu Y, et al. (1997) Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science 275(5297):206-9 |
| abstractText | The interleukin-1beta (IL-1beta) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-gamma inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE-/-) Kupffer cells synthesized the IGIF precursor but failed to process it into the active form. Interferon-gamma and IGIF were diminished in the sera of ICE-/- mice exposed to Propionibacterium acnes and lipopolysaccharide. The lack of multiple proinflammatory cytokines in ICE-/- mice may account for their protection from septic shock. |
