| First Author | Dent AL | Year | 1997 |
| Journal | Science | Volume | 276 |
| Issue | 5312 | Pages | 589-92 |
| PubMed ID | 9110977 | Mgi Jnum | J:39815 |
| Mgi Id | MGI:87164 | Doi | 10.1126/science.276.5312.589 |
| Citation | Dent AL, et al. (1997) Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276(5312):589-92 |
| abstractText | The gene encoding the BCL-6 transcriptional repressor is frequently translocated and mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed myocarditis and pulmonary vasculitis, had no germinal centers, and had increased expression of T helper cell type 2 cytokines. The BCL-6 DNA recognition motif resembled sites bound by the STAT (signal transducers and activators of transcription) transcription factors, which mediate cytokine signaling. BCL-6 could repress interleukin-4 (IL-4)-induced transcription when bound to a site recognized by the IL-4-responsive transcription factor Stat6. Thus, dysregulation of STAT-responsive genes may underlie the inflammatory disease in BCL-6-deficient mice and participate in lymphoid malignancies. |
