| First Author | Beck MA | Year | 1998 |
| Journal | FASEB J | Volume | 12 |
| Issue | 12 | Pages | 1143-9 |
| PubMed ID | 9737717 | Mgi Jnum | J:82372 |
| Mgi Id | MGI:2652784 | Doi | 10.1096/fasebj.12.12.1143 |
| Citation | Beck MA, et al. (1998) Glutathione peroxidase protects mice from viral-induced myocarditis. FASEB J 12(12):1143-9 |
| abstractText | Glutathione peroxidase 1 (GPX-1) is a selenium-dependent enzyme with antioxidant properties. Previous investigations determined that mice deficient in selenium developed myocarditis when infected with a benign strain of coxsackievirus B3 (CVB3/0). To determine whether this effect was mediated by GPX-1, mice with a disrupted Gpx1 gene (Gpx1-/-) were infected with CVB3/0. Gpx1-/- mice developed myocarditis after CVB3/0 infection, whereas infected wild-type mice (Gpx1+/+) were resistant. Sequencing of viruses recovered from Gpx1(-/-)-infected mice demonstrated seven nucleotide changes in the viral genome, of which three occurred at the G residue, the most easily oxidized base. No changes were found in virus isolated from Gpx1+/+ mice. These results demonstrate that GPX-1 provides protection against viral-induced damage in vivo due to mutations in the viral genome of a benign virus. |
