| First Author | Sora I | Year | 1997 |
| Journal | Eur J Pharmacol | Volume | 324 |
| Issue | 2-3 | Pages | R1-2 |
| PubMed ID | 9145787 | Mgi Jnum | J:128705 |
| Mgi Id | MGI:3767891 | Doi | 10.1016/s0014-2999(97)10016-4 |
| Citation | Sora I, et al. (1997) The mu-opioid receptor is necessary for [D-Pen2,D-Pen5]enkephalin-induced analgesia. Eur J Pharmacol 324(2-3):R1-2 |
| abstractText | Interactions between delta-opioid receptors and morphine-preferring mu-opioid receptor subtypes have been suggested. Availability of transgenic mu-opioid receptor knockout mice allows assessment of mu-opioid receptor roles in the analgesia produced by the classical delta-opioid receptor agonist [D-Pen2,D-Pen5]enkephalin (DPDPE) in hot-plate and tail-flick tests. DPDPE analgesia was dramatically reduced in mu-opioid receptor knockout mice in a gene-dose-dependent fashion. The analgesia induced by this classic delta-opioid receptor agonist depends on intact mu-opioid receptors, suggesting that selective delta-opioid receptor drugs may require mu-opioid receptor occupancies for full efficacy. |
