| First Author | Han W | Year | 2006 |
| Journal | Neuroreport | Volume | 17 |
| Issue | 9 | Pages | 941-4 |
| PubMed ID | 16738492 | Mgi Jnum | J:110123 |
| Mgi Id | MGI:3639390 | Doi | 10.1097/01.wnr.0000221829.87974.ad |
| Citation | Han W, et al. (2006) Increased body weight in mice lacking mu-opioid receptors. Neuroreport 17(9):941-944 |
| abstractText | Opioids have been suggested to affect feeding behaviour. To clarify the role of mu-opioid receptors in feeding, we measured several parameters relating to food intake in mu-opioid receptor knockout mice. Here, we show that the knockout mice had increased body weight in adulthood, although the intake amount of standard food was similar between the wild-type and knockout littermates. Serum markers for energy homeostasis were not significantly altered in the knockout mice. Hypothalamic neuropeptide Y mRNA, however, was higher in knockouts than in wild-type mice. Our results suggest that the up-regulated expression of neuropeptide Y mRNA might contribute to the increased weights of adult mu-opioid receptor knockout mice. |
