| First Author | Almad AA | Year | 2022 |
| Journal | Proc Natl Acad Sci U S A | Volume | 119 |
| Issue | 13 | Pages | e2107391119 |
| PubMed ID | 35312356 | Mgi Jnum | J:357607 |
| Mgi Id | MGI:7276118 | Doi | 10.1073/pnas.2107391119 |
| Citation | Almad AA, et al. (2022) Cx43 hemichannels contribute to astrocyte-mediated toxicity in sporadic and familial ALS. Proc Natl Acad Sci U S A 119(13):e2107391119 |
| abstractText | SignificanceOur results demonstrate that connexin 43 hemichannels are the conduits for amyotrophic lateral sclerosis (ALS) astrocyte-mediated motor neuron toxicity and disease spread, acting as a common mechanism that can target both familial ALS and sporadic ALS populations. Furthermore, our present work provides proof of principle that tonabersat, as a drug already studied in clinical trials for other indications, could serve as a potential ALS therapeutic. |
