| First Author | Mohrs M | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 9 | Pages | 842-7 |
| PubMed ID | 11526400 | Mgi Jnum | J:125684 |
| Mgi Id | MGI:3759399 | Doi | 10.1038/ni0901-842 |
| Citation | Mohrs M, et al. (2001) Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nat Immunol 2(9):842-7 |
| abstractText | Mechanisms that underlie the patterning of cytokine expression in T helper (T(H)) cell subsets remain incompletely defined. An evolutionarily conserved approximately 400-bp noncoding sequence in the intergenic region between the genes Il4 and Il13, designated conserved noncoding sequence 1 (CNS-1), was deleted in mice. The capacity to develop T(H)2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1(-/-) mice maintained their capacity to produce interleukin 4. A T cell-specific element critical for the optimal expression of type 2 cytokines may represent the evolution of a regulatory sequence exploited by adaptive immunity. |
