| First Author | Wang WA | Year | 2017 |
| Journal | Sci Rep | Volume | 7 |
| Issue | 1 | Pages | 5941 |
| PubMed ID | 28725049 | Mgi Jnum | J:274131 |
| Mgi Id | MGI:6296236 | Doi | 10.1038/s41598-017-05734-x |
| Citation | Wang WA, et al. (2017) Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis. Sci Rep 7(1):5941 |
| abstractText | A direct link between Ca(2+) and lipid homeostasis has not been definitively demonstrated. In this study, we show that manipulation of ER Ca(2+) causes the re-distribution of a portion of the intracellular unesterified cholesterol to a pool that is not available to the SCAP-SREBP complex. The SREBP processing pathway in ER Ca(2+) depleted cells remained fully functional and responsive to changes in cellular cholesterol status but differed unexpectedly in basal activity. These findings establish the role of Ca(2+) in determining the reference set-point for controlling cellular lipid homeostasis. We propose that ER Ca(2+) status is an important determinant of the basal sensitivity of the sterol sensing mechanism inherent to the SREBP processing pathway. |
