| First Author | Loughna S | Year | 2001 |
| Journal | Mol Cell | Volume | 7 |
| Issue | 1 | Pages | 233-9 |
| PubMed ID | 11172728 | Mgi Jnum | J:67322 |
| Mgi Id | MGI:1930385 | Doi | 10.1016/s1097-2765(01)00171-x |
| Citation | Loughna S, et al. (2001) A combinatorial role of angiopoietin-1 and orphan receptor TIE1 pathways in establishing vascular polarity during angiogenesis. Mol Cell 7(1):233-9 |
| abstractText | Vascular polarity is a fundamental feature of angiogenesis and left-right asymmetry of the vascular network. Contrary to this importance, the molecular basis of vascular polarity is completely unknown. In this report, we show that the combinatorial function of angiopoietin-1 and the orphan receptor TIE1 is critical specifically for the development of the right-hand side venous system but is dispensable for the left-hand side venous system. Furthermore, our current finding reveals the existence of a distinct genetic program for the establishment of the right-hand side and left-hand side vascular networks well before the network asymmetry becomes morphologically discernible. |
