| First Author | Priya R | Year | 2018 |
| Journal | Cell Rep | Volume | 22 |
| Issue | 7 | Pages | 1695-1709 |
| PubMed ID | 29444424 | Mgi Jnum | J:268845 |
| Mgi Id | MGI:6272446 | Doi | 10.1016/j.celrep.2018.01.007 |
| Citation | Priya R, et al. (2018) Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism. Cell Rep 22(7):1695-1709 |
| abstractText | We demonstrate that cortical interneurons derived from ventral eminences, including the caudal ganglionic eminence, undergo programmed cell death. Moreover, with the exception of VIP interneurons, this occurs in a manner that is activity-dependent. In addition, we demonstrate that, within interneurons, Calcineurin, a calcium-dependent protein phosphatase, plays a critical role in sequentially linking activity to maturation (E15-P5) and survival (P5-P20). Specifically, embryonic inactivation of Calcineurin results in a failure of interneurons to morphologically mature and prevents them from undergoing apoptosis. By contrast, early postnatal inactivation of Calcineurin increases apoptosis. We conclude that Calcineurin serves a dual role of promoting first the differentiation of interneurons and, subsequently, their survival. |
