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Publication : Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia.

First Author  Dessing MC Year  2006
Journal  Infect Immun Volume  74
Issue  12 Pages  7021-3
PubMed ID  16982835 Mgi Jnum  J:115915
Mgi Id  MGI:3692461 Doi  10.1128/IAI.00977-06
Citation  Dessing MC, et al. (2006) Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia. Infect Immun 74(12):7021-3
abstractText  To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality.
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