| First Author | Zhang H | Year | 2013 |
| Journal | Cancer Cell | Volume | 24 |
| Issue | 5 | Pages | 575-88 |
| PubMed ID | 24183681 | Mgi Jnum | J:206602 |
| Mgi Id | MGI:5551545 | Doi | 10.1016/j.ccr.2013.09.018 |
| Citation | Zhang H, et al. (2013) Sox4 is a key oncogenic target in C/EBPalpha mutant acute myeloid leukemia. Cancer Cell 24(5):575-88 |
| abstractText | Mutation or epigenetic silencing of the transcription factor C/EBPalpha is observed in approximately 10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but downstream targets relevant for leukemogenesis are not known. Here, we identify Sox4 as a direct target of C/EBPalpha whereby its expression is inversely correlated with C/EBPalpha activity. Downregulation of Sox4 abrogated increased self-renewal of leukemic cells and restored their differentiation. Gene expression profiles of leukemia-initiating cells (LICs) from both Sox4 overexpression and murine C/EBPalpha mutant AML models clustered together but differed from other types of AML. Our data demonstrate that Sox4 overexpression resulting from C/EBPalpha inactivation contributes to the development of leukemia with a distinct LIC phenotype. |
