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Publication : Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

First Author  Inoue D Year  2016
Journal  Cancer Cell Volume  30
Issue  3 Pages  371-373
PubMed ID  27622329 Mgi Jnum  J:234979
Mgi Id  MGI:5792586 Doi  10.1016/j.ccell.2016.08.013
Citation  Inoue D, et al. (2016) Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities. Cancer Cell 30(3):371-3
abstractText  In this issue of Cancer Cell, Obeng et al. identify the consequences of expressing the most common mutation in the spliceosomal gene SF3B1 on hematopoiesis. The knockin mouse model described represents a valuable tool to dissect the effects of SF3B1 mutations on transformation, splicing, and less well-characterized functions of SF3B1.
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