| First Author | Hao Z | Year | 2001 |
| Journal | J Exp Med | Volume | 194 |
| Issue | 8 | Pages | 1151-64 |
| PubMed ID | 11602643 | Mgi Jnum | J:72214 |
| Mgi Id | MGI:2152002 | Doi | 10.1084/jem.194.8.1151 |
| Citation | Hao Z, et al. (2001) Homeostasis of peripheral b cells in the absence of b cell influx from the bone marrow. J Exp Med 194(8):1151-64 |
| abstractText | To study homeostasis of peripheral B lymphocytes in the absence of B cell influx from the bone marrow, we generated a mouse mutant in which the recombination-activating gene (RAG)-2 can be inducibly deleted. When RAG-2 was deleted at the age of 8-10 wk, splenic naive follicular B cells were gradually lost over a year of observation, with a half-life of approximately 4.5 mo. By contrast, the pool of marginal zone B cells in the spleen and of B-1 cells in the peritoneal cavity were kept at normal level. In lymph nodes, approximately 90% of the B cells were lost within 4 mo, and B cell numbers remained constant thereafter. Mice in which RAG-2 was deleted at birth maintained a small population of activated B cells with an increased proportion of marginal zone B cells. Additionally, an increase of the pool of IgM secreting cells and B-1a cells was observed. |
