| First Author | Laidlaw BJ | Year | 2019 |
| Journal | J Exp Med | Volume | 216 |
| Issue | 7 | Pages | 1487-1496 |
| PubMed ID | 31160320 | Mgi Jnum | J:282548 |
| Mgi Id | MGI:6364273 | Doi | 10.1084/jem.20190114 |
| Citation | Laidlaw BJ, et al. (2019) Sphingosine-1-phosphate receptor 2 restrains egress of gammadelta T cells from the skin. J Exp Med 216(7):1487-1496 |
| abstractText | Maintenance of a population of IL-17-committed gammadelta T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating gammadelta T cell retention within the dermis remain poorly understood. Here, we find that sphingosine-1-phosphate receptor 2 (S1PR2) acts in a cell-intrinsic manner to oppose gammadelta T cell migration from the dermis to the skin draining lymph node (dLN). Migration of dermal gammadelta T cells to the dLN under steady-state conditions occurs in an S1PR1-dependent manner. S1PR1 and CD69 are reciprocally expressed on dermal gammadelta T cells, with loss of CD69 associated with increased S1PR1 expression and enhanced migration to the dLN. gammadelta T cells lacking both S1PR2 and CD69 are impaired in their maintenance within the dermis. These findings provide a mechanism for how IL-17(+) gammadelta T cells establish residence within the dermis and identify a role for S1PR2 in restraining the egress of tissue-resident lymphocytes. |
