| First Author | Hashimoto A | Year | 2000 |
| Journal | J Immunol | Volume | 165 |
| Issue | 4 | Pages | 1738-42 |
| PubMed ID | 10925250 | Mgi Jnum | J:63744 |
| Mgi Id | MGI:1861532 | Doi | 10.4049/jimmunol.165.4.1738 |
| Citation | Hashimoto A, et al. (2000) Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J Immunol 165(4):1738-42 |
| abstractText | Cross-linking of the B cell Ag receptor (BCR) induces the tyrosine phosphorylation of multiple cellular substrates, including phospholipase C (PLC)-gamma 2, which is involved in the activation of the phosphatidylinositol pathway. To assess the importance of PLC-gamma 2 in murine lymphopoiesis, the PLC-gamma 2 gene was inducibly ablated by using IFN-regulated Cre recombinase. Mice with a neonatally induced loss of PLC-gamma 2 function displayed reduced numbers of mature conventional B cells and peritoneal B1 cells and defective responses in vitro to BCR stimulation and in vivo to immunization with thymus-independent type II Ags. In contrast, T cell development and TCR-mediated proliferation were normal. Taken together, PLC-gamma 2 is a critical component of BCR signaling pathways and is required to promote B cell development. |
