| Primary Identifier | MGI:2176173 | Allele Type | Transgenic |
| Attribute String | Recombinase | Gene | Tg(Nes-cre)1Kln |
| Strain of Origin | (C57BL/6 x SJL)F2 | Is Recombinase | true |
| Is Wild Type | false |
| description | Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. |
| molecularNote | This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of a rat nestin (Nes) promoter and the nervous system-specific enhancer present in the second intron. This promoter expresses Cre recombinase in neuronal and glial cell precursors. Cre recombinase activity is present in nervous tissue by embryonic day 11. The transgene was localized to chromosome 12 using FISH with a rat nestin promoter probe (J:180046). The insertion caused a 17 bp deletion. |
