| First Author | Berry RL | Year | 2015 |
| Journal | Dis Model Mech | Volume | 8 |
| Issue | 8 | Pages | 903-17 |
| PubMed ID | 26035382 | Mgi Jnum | J:223918 |
| Mgi Id | MGI:5660659 | Doi | 10.1242/dmm.018523 |
| Citation | Berry RL, et al. (2015) Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice. Dis Model Mech 8(8):903-17 |
| abstractText | Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best-defined subgroup of Wilms' tumours is the group caused by biallelic loss of the WT1 tumour suppressor gene. Here, we describe a developmental series of mouse models with conditional loss of Wt1 in different stages of nephron development before and after the mesenchymal-to-epithelial transition (MET). We demonstrate that Wt1 is essential for normal development at all kidney developmental stages under study. Comparison of genome-wide expression data from the mutant mouse models with human tumour material of mutant or wild-type WT1 datasets identified the stage of origin of human WT1-mutant tumours, and emphasizes fundamental differences between the two human tumour groups due to different developmental stages of origin. |
