| First Author | Zhang Y | Year | 2008 |
| Journal | Neuron | Volume | 60 |
| Issue | 1 | Pages | 84-96 |
| PubMed ID | 18940590 | Mgi Jnum | J:147245 |
| Mgi Id | MGI:3839732 | Doi | 10.1016/j.neuron.2008.09.027 |
| Citation | Zhang Y, et al. (2008) V3 spinal neurons establish a robust and balanced locomotor rhythm during walking. Neuron 60(1):84-96 |
| abstractText | A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3-mediated neurotransmission is selectively blocked by the expression of the tetanus toxin light chain subunit (TeNT), the regularity and robustness of the locomotor rhythm is severely perturbed. A similar degeneration in the locomotor rhythm occurs when the excitability of V3-derived neurons is reduced acutely by ligand-induced activation of the allatostatin receptor. The V3-derived neurons additionally function to balance the locomotor output between both halves of the spinal cord, thereby ensuring a symmetrical pattern of locomotor activity during walking. We propose that the V3 neurons establish a regular and balanced motor rhythm by distributing excitatory drive between both halves of the spinal cord. |
