| First Author | Li X | Year | 2024 |
| Journal | Nat Immunol | Volume | 25 |
| Issue | 6 | Pages | 1110-1122 |
| PubMed ID | 38698086 | Mgi Jnum | J:361279 |
| Mgi Id | MGI:7857089 | Doi | 10.1038/s41590-024-01826-9 |
| Citation | Li X, et al. (2024) Coordinated chemokine expression defines macrophage subsets across tissues. Nat Immunol 25(6):1110-1122 |
| abstractText | Lung-resident macrophages, which include alveolar macrophages and interstitial macrophages (IMs), exhibit a high degree of diversity, generally attributed to different activation states, and often complicated by the influx of monocytes into the pool of tissue-resident macrophages. To gain a deeper insight into the functional diversity of IMs, here we perform comprehensive transcriptional profiling of resident IMs and reveal ten distinct chemokine-expressing IM subsets at steady state and during inflammation. Similar IM subsets that exhibited coordinated chemokine signatures and differentially expressed genes were observed across various tissues and species, indicating conserved specialized functional roles. Other macrophage types shared specific IM chemokine profiles, while also presenting their own unique chemokine signatures. Depletion of CD206(hi) IMs in Pf4(cre)R26(EYFP+DTR) and Pf4(cre)R26(EYFP)Cx3cr1(DTR) mice led to diminished inflammatory cell recruitment, reduced tertiary lymphoid structure formation and fewer germinal center B cells in models of allergen- and infection-driven inflammation. These observations highlight the specialized roles of IMs, defined by their coordinated chemokine production, in regulating immune cell influx and organizing tertiary lymphoid tissue architecture. |
