| First Author | Aguado F | Year | 2009 |
| Journal | J Neurosci | Volume | 29 |
| Issue | 2 | Pages | 328-33 |
| PubMed ID | 19144833 | Mgi Jnum | J:144500 |
| Mgi Id | MGI:3831043 | Doi | 10.1523/JNEUROSCI.5252-08.2009 |
| Citation | Aguado F, et al. (2009) The CREB/CREM transcription factors negatively regulate early synaptogenesis and spontaneous network activity. J Neurosci 29(2):328-33 |
| abstractText | The family of CREB (cAMP response element-binding protein) transcription factors are involved in a variety of biological processes including the development and plasticity of the nervous system. In the maturing and adult brain, CREB genes are required for activity-dependent processes, including synaptogenesis, refinement of connections and long-term potentiation. Here, we use CREB1(Nescre)CREM(-/-) (cAMP-responsive element modulator) mutants to investigate the role of these genes in stimulus-independent patterns of neural activity at early stages. We show that lack of CREB/CREM genes specifically in neural tissue leads to increased synaptogenesis and to a dramatic increase in the levels of spontaneous network activity at embryonic stages. Thus, the functions of CREB/CREM genes in neural activity differ in distinct periods of neural development. |
