| First Author | Zhao H | Year | 2001 |
| Journal | Cell | Volume | 104 |
| Issue | 5 | Pages | 651-60 |
| PubMed ID | 11257220 | Mgi Jnum | J:77304 |
| Mgi Id | MGI:2181333 | Doi | 10.1016/s0092-8674(01)00262-8 |
| Citation | Zhao H, et al. (2001) X inactivation of the OCNC1 channel gene reveals a role for activity-dependent competition in the olfactory system. Cell 104(5):651-60 |
| abstractText | The organization of neuronal systems is often dependent on activity and competition between cells. In olfaction, the X-linked OCNC1 channel subunit is subject to random inactivation and is essential for odorant-evoked activity. Reporter-tagged OCNC1 mutant mice permit the visualization of OCNC1-deficient olfactory neurons and their projections. In heterozygous females, X inactivation creates a mosaic with two populations of genetically distinct neurons. OCNC1-deficient neurons are slowly and specifically depleted from the olfactory epithelium and display unusual patterns of projection to the olfactory bulb. Remarkably, this depletion is dependent on odorant exposure and is reversed by odorant deprivation. This suggests that odorants and the activity they evoke are critical for neuronal survival in a competitive environment and implicate evoked activity in the organization and maintenance of the olfactory system. |
