First Author | Yang G | Year | 2015 |
Journal | Nat Methods | Volume | 12 |
Issue | 2 | Pages | 137-9 |
PubMed ID | 25486061 | Mgi Jnum | J:222844 |
Mgi Id | MGI:5645757 | Doi | 10.1038/nmeth.3207 |
Citation | Yang G, et al. (2015) Genetic targeting of chemical indicators in vivo. Nat Methods 12(2):137-9 |
abstractText | Fluorescent protein reporters have become the mainstay for tracing cellular circuitry in vivo but are limited in their versatility. Here we generated Cre-dependent reporter mice expressing the Snap-tag to target synthetic indicators to cells. Snap-tag labeling worked efficiently and selectively in vivo, allowing for both the manipulation of behavior and monitoring of cellular fluorescence from the same reporter. |