| First Author | Oh-Hora M | Year | 2008 |
| Journal | Nat Immunol | Volume | 9 |
| Issue | 4 | Pages | 432-43 |
| PubMed ID | 18327260 | Mgi Jnum | J:133262 |
| Mgi Id | MGI:3778155 | Doi | 10.1038/ni1574 |
| Citation | Oh-Hora M, et al. (2008) Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol 9(4):432-43 |
| abstractText | Store-operated Ca2+ entry through calcium release-activated calcium channels is the chief mechanism for increasing intracellular Ca2+ in immune cells. Here we show that mouse T cells and fibroblasts lacking the calcium sensor STIM1 had severely impaired store-operated Ca2+ influx, whereas deficiency in the calcium sensor STIM2 had a smaller effect. However, T cells lacking either STIM1 or STIM2 had much less cytokine production and nuclear translocation of the transcription factor NFAT. T cell-specific ablation of both STIM1 and STIM2 resulted in a notable lymphoproliferative phenotype and a selective decrease in regulatory T cell numbers. We conclude that both STIM1 and STIM2 promote store-operated Ca2+ entry into T cells and fibroblasts and that STIM proteins are required for the development and function of regulatory T cells. |
