| First Author | Xiao C | Year | 2007 |
| Journal | Cell | Volume | 131 |
| Issue | 1 | Pages | 146-59 |
| PubMed ID | 17923094 | Mgi Jnum | J:127234 |
| Mgi Id | MGI:3763440 | Doi | 10.1016/j.cell.2007.07.021 |
| Citation | Xiao C, et al. (2007) MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 131(1):146-59 |
| abstractText | MiR-150 is a microRNA (miRNA) specifically expressed in mature lymphocytes, but not their progenitors. A top predicted target of miR-150 is c-Myb, a transcription factor controlling multiple steps of lymphocyte development. Combining loss- and gain-of-function gene targeting approaches for miR-150 with conditional and partial ablation of c-Myb, we show that miR-150 indeed controls c-Myb expression in vivo in a dose-dependent manner over a narrow range of miRNA and c-Myb concentrations and that this dramatically affects lymphocyte development and response. Our results identify a key transcription factor as a critical target of a stage-specifically expressed miRNA in lymphocytes and suggest that this and perhaps other miRNAs have evolved to control the expression of just a few critical target proteins in particular cellular contexts. |
