| First Author | Gérard C | Year | 2018 |
| Journal | Oncotarget | Volume | 9 |
| Issue | 98 | Pages | 37185-37199 |
| PubMed ID | 30647853 | Mgi Jnum | J:298188 |
| Mgi Id | MGI:6457226 | Doi | 10.18632/oncotarget.26449 |
| Citation | Gerard C, et al. (2018) Microenvironment-derived ADAM28 prevents cancer dissemination. Oncotarget 9(98):37185-37199 |
| abstractText | Previous studies have linked cancer cell-associated ADAM28 expression with tumor progression and metastatic dissemination. However, the role of host-derived ADAM28 in cancer dissemination processes remains unclear. Genetically engineered-mice fully deficient for ADAM28 unexpectedly display increased lung colonization by pulmonary, melanoma or breast tumor cells. In experimental tumor cell dissemination models, host ADAM28 deficiency is further associated with a decreased lung infiltration by CD8(+) T lymphocytes. Notably, naive ADAM28-deficient mice already display a drastic reduction of CD8(+) T cells in spleen which is further observed in lungs. Interestingly, ex vivo CD8(+) T cell characterization revealed that ADAM28-deficiency does not impact proliferation, migration nor activation of CD8(+) T cells. Our data highlight a functional role of ADAM28 in T cell mobilization and point to an unexpected protective role for host ADAM28 against metastasis. |
