| First Author | Tan CL | Year | 2013 |
| Journal | Science | Volume | 342 |
| Issue | 6163 | Pages | 1254-8 |
| PubMed ID | 24311694 | Mgi Jnum | J:205260 |
| Mgi Id | MGI:5544497 | Doi | 10.1126/science.1244193 |
| Citation | Tan CL, et al. (2013) MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science 342(6163):1254-8 |
| abstractText | The control of motor behavior in animals and humans requires constant adaptation of neuronal networks to signals of various types and strengths. We found that microRNA-128 (miR-128), which is expressed in adult neurons, regulates motor behavior by modulating neuronal signaling networks and excitability. miR-128 governs motor activity by suppressing the expression of various ion channels and signaling components of the extracellular signal-regulated kinase ERK2 network that regulate neuronal excitability. In mice, a reduction of miR-128 expression in postnatal neurons causes increased motor activity and fatal epilepsy. Overexpression of miR-128 attenuates neuronal responsiveness, suppresses motor activity, and alleviates motor abnormalities associated with Parkinson's-like disease and seizures in mice. These data suggest a therapeutic potential for miR-128 in the treatment of epilepsy and movement disorders. |
