| First Author | Masson F | Year | 2013 |
| Journal | J Immunol | Volume | 190 |
| Issue | 9 | Pages | 4585-94 |
| PubMed ID | 23536629 | Mgi Jnum | J:195516 |
| Mgi Id | MGI:5484709 | Doi | 10.4049/jimmunol.1300099 |
| Citation | Masson F, et al. (2013) Id2-Mediated Inhibition of E2A Represses Memory CD8+ T Cell Differentiation. J Immunol 190(9):4585-94 |
| abstractText | The transcription factor inhibitor of DNA binding (Id)2 modulates T cell fate decisions, but the molecular mechanism underpinning this regulation is unclear. In this study we show that loss of Id2 cripples effector differentiation and instead programs CD8(+) T cells to adopt a memory fate with increased Eomesodermin and Tcf7 expression. We demonstrate that Id2 restrains CD8(+) T cell memory differentiation by inhibiting E2A-mediated direct activation of Tcf7 and that Id2 expression level mirrors T cell memory recall capacity. As a result of the defective effector differentiation, Id2-deficient CD8(+) T cells fail to induce sufficient Tbx21 expression to generate short-lived effector CD8(+) T cells. Our findings reveal that the Id2/E2A axis orchestrates T cell differentiation through the induction or repression of downstream transcription factors essential for effector and memory T cell differentiation. |
