| First Author | Sobajima M | Year | 2022 |
| Journal | Biochem Biophys Res Commun | Volume | 611 |
| Pages | 165-171 | PubMed ID | 35489203 |
| Mgi Jnum | J:333666 | Mgi Id | MGI:7281194 |
| Doi | 10.1016/j.bbrc.2022.04.038 | Citation | Sobajima M, et al. (2022) The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion. Biochem Biophys Res Commun 611:165-171 |
| abstractText | Stress-inducible transcription factor ATF4 is essential for survival and identity of beta-cell during stress conditions. However, the physiological role of ATF4 in beta-cell function is not yet completely understood. To understand the role of ATF4 in glucose-stimulated insulin secretion (GSIS), beta-cell-specific Atf4 knockout (betaAtf4KO) mice were phenotypically characterized. Insulin secretion and mechanistic analyses were performed using islets from control Atf4f/f and betaAtf4KO mice to assess key regulators for triggering and amplifying signals for GSIS. betaAtf4KO mice displayed glucose intolerance due to reduced insulin secretion. Moreover, betaAtf4KO islets exhibited a decrease in both the insulin content and first-phase insulin secretion. The analysis of betaAtf4KO islets showed that ATF4 is required for insulin production and glucose-stimulated ATP and cAMP production. The results demonstrate that ATF4 contributes to the multifaceted regulatory process in GSIS even under stress-free conditions. |
