| First Author | Tournier C | Year | 2000 |
| Journal | Science | Volume | 288 |
| Issue | 5467 | Pages | 870-4 |
| PubMed ID | 10797012 | Mgi Jnum | J:137332 |
| Mgi Id | MGI:3798819 | Doi | 10.1126/science.288.5467.870 |
| Citation | Tournier C, et al. (2000) Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288(5467):870-4 |
| abstractText | The c-Jun NH2-terminal kinase (JNK) is activated when cells are exposed to ultraviolet (UV) radiation. However, the functional consequence of JNK activation in UV-irradiated cells has not been established. It is shown here that JNK is required for UV-induced apoptosis in primary murine embryonic fibroblasts. Fibroblasts with simultaneous targeted disruptions of all the functional Jnk genes were protected against UV-stimulated apoptosis. The absence of JNK caused a defect in the mitochondrial death signaling pathway, including the failure to release cytochrome c. These data indicate that mitochondria are influenced by proapoptotic signal transduction through the JNK pathway. |
