| First Author | Iguchi T | Year | 2015 |
| Journal | J Immunol | Volume | 195 |
| Issue | 3 | Pages | 982-93 |
| PubMed ID | 26136427 | Mgi Jnum | J:271921 |
| Mgi Id | MGI:6282308 | Doi | 10.4049/jimmunol.1500602 |
| Citation | Iguchi T, et al. (2015) BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells. J Immunol 195(3):982-93 |
| abstractText | Many members of the BTB-ZF family have been shown to play important roles in lymphocyte development and function. The role of zinc finger Znf131 (also known as Zbtb35) in T cell lineage was elucidated through the production of mice with floxed allele to disrupt at different stages of development. In this article, we present that Znf131 is critical for T cell development during double-negative to double-positive stage, with which significant cell expansion triggered by the pre-TCR signal is coupled. In mature T cells, Znf131 is required for the activation of effector genes, as well as robust proliferation induced upon TCR signal. One of the cyclin-dependent kinase inhibitors, p21(Cip1) encoded by cdkn1a gene, is one of the targets of Znf131. The regulation of T cell proliferation by Znf131 is in part attributed to its suppression on the expression of p21(Cip1). |
