| First Author | Ghuman H | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 7320 |
| PubMed ID | 37951968 | Mgi Jnum | J:342614 |
| Mgi Id | MGI:7550036 | Doi | 10.1038/s41467-023-43081-w |
| Citation | Ghuman H, et al. (2023) Emergence of task-related spatiotemporal population dynamics in transplanted neurons. Nat Commun 14(1):7320 |
| abstractText | Loss of nervous system tissue after severe brain injury is a main determinant of poor functional recovery. Cell transplantation is a promising method to restore lost tissue and function, yet it remains unclear if transplanted neurons can demonstrate the population level dynamics important for movement control. Here we present a comprehensive approach for long-term single neuron monitoring and manipulation of transplanted embryonic cortical neurons after cortical injury in adult male mice performing a prehension task. The observed patterns of population activity in the transplanted network strongly resembled that of healthy networks. Specifically, the task-related spatiotemporal activity patterns of transplanted neurons could be represented by latent factors that evolve within a low dimensional manifold. We also demonstrate reliable modulation of the transplanted networks using minimally invasive epidural stimulation. Our approach may allow greater insight into how restoration of cell-type specific network dynamics in vivo can restore motor function. |
