| First Author | Teng J | Year | 2005 |
| Journal | Nat Cell Biol | Volume | 7 |
| Issue | 5 | Pages | 474-82 |
| PubMed ID | 15834408 | Mgi Jnum | J:98470 |
| Mgi Id | MGI:3578508 | Doi | 10.1038/ncb1249 |
| Citation | Teng J, et al. (2005) The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol 7(5):474-82 |
| abstractText | In the developing brain, the organization of the neuroepithelium is maintained by a critical balance between proliferation and cell-cell adhesion of neural progenitor cells. The molecular mechanisms that underlie this are still largely unknown. Here, through analysis of a conditional knockout mouse for the Kap3 gene, we show that post-Golgi transport of N-cadherin by the KIF3 molecular motor complex is crucial for maintaining this balance. N-cadherin and beta-catenin associate with the KIF3 complex by co-immunoprecipitation, and colocalize with KIF3 in cells. Furthermore, in KAP3-deficient cells, the subcellular localization of N-cadherin was disrupted. Taken together, these results suggest a potential tumour-suppressing activity for this molecular motor. |
