| First Author | Drinnenberg A | Year | 2018 |
| Journal | Neuron | Volume | 99 |
| Issue | 1 | Pages | 117-134.e11 |
| PubMed ID | 29937281 | Mgi Jnum | J:328651 |
| Mgi Id | MGI:6269077 | Doi | 10.1016/j.neuron.2018.06.001 |
| Citation | Drinnenberg A, et al. (2018) How Diverse Retinal Functions Arise from Feedback at the First Visual Synapse. Neuron 99(1):117-134.e11 |
| abstractText | Many brain regions contain local interneurons of distinct types. How does an interneuron type contribute to the input-output transformations of a given brain region? We addressed this question in the mouse retina by chemogenetically perturbing horizontal cells, an interneuron type providing feedback at the first visual synapse, while monitoring the light-driven spiking activity in thousands of ganglion cells, the retinal output neurons. We uncovered six reversible perturbation-induced effects in the response dynamics and response range of ganglion cells. The effects were enhancing or suppressive, occurred in different response epochs, and depended on the ganglion cell type. A computational model of the retinal circuitry reproduced all perturbation-induced effects and led us to assign specific functions to horizontal cells with respect to different ganglion cell types. Our combined experimental and theoretical work reveals how a single interneuron type can differentially shape the dynamical properties of distinct output channels of a brain region. |
