| First Author | Liang Y | Year | 2016 |
| Journal | Sci Rep | Volume | 6 |
| Pages | 29479 | PubMed ID | 27378170 |
| Mgi Jnum | J:254098 | Mgi Id | MGI:6101913 |
| Doi | 10.1038/srep29479 | Citation | Liang Y, et al. (2016) Conditional ablation of TGF-beta signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model. Sci Rep 6:29479 |
| abstractText | The role of transforming growth factor-beta (TGF-beta) signaling in cancer progression is still under debate. To determine the function of TGF-beta signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We found the ablation of TGF-beta signaling could inhibit the cancer cell proliferation, cancer stem cell population and EMT, hence suppressed the invasive cancer progression, which is similar with the result of TGF-beta receptor I inhibitor treatment. These findings recognize the roles and mechanisms of TGF-beta signaling in bladder cancer progression in vivo for the first time. |
