| First Author | McFarlane E | Year | 2019 |
| Journal | Front Immunol | Volume | 10 |
| Pages | 1957 | PubMed ID | 31475014 |
| Mgi Jnum | J:281550 | Mgi Id | MGI:6378057 |
| Doi | 10.3389/fimmu.2019.01957 | Citation | McFarlane E, et al. (2019) IL-4 Mediated Resistance of BALB/c Mice to Visceral Leishmaniasis Is Independent of IL-4Ralpha Signaling via T Cells. Front Immunol 10:1957 |
| abstractText | Previous studies infecting global IL-4Ralpha(-/-), IL-4(-/-), and IL-13(-/-)mice on a BALB/c background with the visceralizing parasite Leishmania donovani have shown that the T helper 2 cytokines, IL-4, and IL-13, play influential but not completely overlapping roles in controlling primary infection. Subsequently, using macrophage/neutrophil-specific IL-4Ralpha deficient BALB/c mice, we demonstrated that macrophage/neutrophil unresponsiveness to IL-4 and IL-13 did not have a detrimental effect during L. donovani infection. Here we expand on these findings and show that CD4(+) T cell-(Lck(cre)), as well as pan T cell-(iLck(cre)) specific IL-4Ralpha deficient mice, on a BALB/c background, unlike global IL-4Ralpha deficient mice, are also not adversely affected in terms of resistance to primary infection with L. donovani. Our analysis suggested only a transient and tissue specific impact on disease course due to lack of IL-4Ralpha on T cells, limited to a reduced hepatic parasite burden at day 30 post-infection. Consequently, the protective role(s) demonstrated for IL-4 and IL-13 during L. donovani infection are mediated by IL-4Ralpha-responsive cell(s) other than macrophages, neutrophils and T cells. |
