| First Author | Yanger K | Year | 2013 |
| Journal | Genes Dev | Volume | 27 |
| Issue | 7 | Pages | 719-24 |
| PubMed ID | 23520387 | Mgi Jnum | J:195278 |
| Mgi Id | MGI:5477848 | Doi | 10.1101/gad.207803.112 |
| Citation | Yanger K, et al. (2013) Robust cellular reprogramming occurs spontaneously during liver regeneration. Genes Dev 27(7):719-24 |
| abstractText | Cellular reprogramming-the ability to interconvert distinct cell types with defined factors-is transforming the field of regenerative medicine. However, this phenomenon has rarely been observed in vivo without exogenous factors. Here, we report that activation of Notch, a signaling pathway that mediates lineage segregation during liver development, is sufficient to reprogram hepatocytes into biliary epithelial cells (BECs). Moreover, using lineage tracing, we show that hepatocytes undergo widespread hepatocyte-to-BEC reprogramming following injuries that provoke a biliary response, a process requiring Notch. These results provide direct evidence that mammalian regeneration prompts extensive and dramatic changes in cellular identity under injury conditions. |
