| First Author | Davy A | Year | 2007 |
| Journal | Dev Biol | Volume | 304 |
| Issue | 1 | Pages | 182-93 |
| PubMed ID | 17223098 | Mgi Jnum | J:143845 |
| Mgi Id | MGI:3829150 | Doi | 10.1016/j.ydbio.2006.12.028 |
| Citation | Davy A, et al. (2007) Ephrin-B2 forward signaling regulates somite patterning and neural crest cell development. Dev Biol 304(1):182-93 |
| abstractText | Genetic studies in the mouse have implicated ephrin-B2 (encoded by the gene Efnb2) in blood vessel formation, cardiac development and remodeling of the lymphatic vasculature. Here we report that loss of ephrin-B2 leads to defects in populations of cranial and trunk neural crest cells (NCC) and to defective somite development. In addition, we show that Efnb1/Efnb2 double heterozygous embryos exhibit phenotypes in a number of NCC derivatives. Expression of one copy of a mutant version of Efnb2 that lacks tyrosine phosphorylation sites was sufficient to rescue the embryonic phenotypes associated with loss of Efnb2. Our results uncover an important role for ephrin-B2 in NCC and somites during embryogenesis and suggest that ephrin-B2 exerts many of its embryonic function via activation of forward signaling. |
