| First Author | Sullivan BM | Year | 2011 |
| Journal | Nat Immunol | Volume | 12 |
| Issue | 6 | Pages | 527-35 |
| PubMed ID | 21552267 | Mgi Jnum | J:172122 |
| Mgi Id | MGI:5004735 | Doi | 10.1038/ni.2036 |
| Citation | Sullivan BM, et al. (2011) Genetic analysis of basophil function in vivo. Nat Immunol 12(6):527-35 |
| abstractText | Contributions by basophils to allergic and helminth immunity remain incompletely defined. Using sensitive interleukin 4 (Il4) reporter alleles, we demonstrate here that basophil IL-4 production occurs by a CD4(+) T cell-dependent process restricted to the peripheral tissues affected. We genetically marked and achieved specific deletion of basophils and found that basophils did not mediate T helper type 2 (T(H)2) priming in vivo. Two-photon imaging confirmed that basophils did not interact with antigen-specific T cells in lymph nodes but engaged in prolonged serial interactions with T cells in lung tissues. Although targeted deletion of IL-4 and IL-13 in either CD4(+) T cells or basophils had a minimal effect on worm clearance, deletion from both lineages demonstrated a nonredundant role for basophil cytokines in primary helminth immunity. |
