| First Author | Tatsumi N | Year | 2021 |
| Journal | Sci Immunol | Volume | 6 |
| Issue | 66 | Pages | eabg0336 |
| PubMed ID | 34890253 | Mgi Jnum | J:321812 |
| Mgi Id | MGI:7254842 | Doi | 10.1126/sciimmunol.abg0336 |
| Citation | Tatsumi N, et al. (2021) Effective CD4 T cell priming requires repertoire scanning by CD301b(+) migratory cDC2 cells upon lymph node entry. Sci Immunol 6(66):eabg0336 |
| abstractText | During the initiation of adaptive immune responses, millions of lymphocytes must be scanned to find the few cognate clones. The activation mechanisms of CD4 T cells have been extensively studied, but the cellular mechanisms that drive selection of cognate clones are not completely understood. Here, we show that recently homed naive polyclonal CD4 T cells are temporarily retained before leaving the lymph node. This stop-and-go traffic of CD4 T cells provides an adequate time window for efficient scanning and timely priming of antigen-specific cognate clones. CD301b(+) DCs, a major subset of migratory cDC2 cells, localize to the areas around high endothelial venules, where they retain incoming polyclonal CD4 T cells through MHCII-dependent but antigen-independent mechanisms, while concurrently providing cognate stimuli for priming. These results indicate that CD301b(+) DCs function as an immunological "display window" for CD4 T cells to efficiently scan their antigen specificity. |
