| First Author | Sharan SK | Year | 1997 |
| Journal | Nature | Volume | 386 |
| Issue | 6627 | Pages | 804-10 |
| PubMed ID | 9126738 | Mgi Jnum | J:39764 |
| Mgi Id | MGI:87113 | Doi | 10.1038/386804a0 |
| Citation | Sharan SK, et al. (1997) Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 [see comments]. Nature 386(6627):804-10 |
| abstractText | Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2-deficient embryos, their radiation sensitivity, and the association of Brca2 with Rad51 indicate that Brca2 may be an essential cofactor in the Rad51-dependent DNA repair of double-strand breaks, thereby explaining the tumour-suppressor function of Brca2. |
