| First Author | Tsien JZ | Year | 1996 |
| Journal | Cell | Volume | 87 |
| Issue | 7 | Pages | 1317-26 |
| PubMed ID | 8980237 | Mgi Jnum | J:66344 |
| Mgi Id | MGI:1928325 | Doi | 10.1016/s0092-8674(00)81826-7 |
| Citation | Tsien JZ, et al. (1996) Subregion- and cell type-restricted gene knockout in mouse brain. Cell 87(7):1317-26 |
| abstractText | Using the phage P1-derived Cre/loxP recombination system, we have developed a method to create mice in which the deletion (knockout) of virtually any gene of interest is restricted to a subregion or a specific cell type in the brain such as the pyramidal cells of the hippocampal CA1 region. The Cre/loxP recombination-based gene deletion appears to require a certain level of Cre protein expression. The brain subregional restricted gene knockout should allow a more precise analysis of the impact of a gene mutation on animal behaviors. |
