| First Author | Song YH | Year | 2017 |
| Journal | Neuron | Volume | 93 |
| Issue | 4 | Pages | 940-954.e6 |
| PubMed ID | 28162806 | Mgi Jnum | J:253221 |
| Mgi Id | MGI:6109244 | Doi | 10.1016/j.neuron.2017.01.006 |
| Citation | Song YH, et al. (2017) A Neural Circuit for Auditory Dominance over Visual Perception. Neuron 93(4):940-954.e6 |
| abstractText | When conflicts occur during integration of visual and auditory information, one modality often dominates the other, but the underlying neural circuit mechanism remains unclear. Using auditory-visual discrimination tasks for head-fixed mice, we found that audition dominates vision in a process mediated by interaction between inputs from the primary visual (VC) and auditory (AC) cortices in the posterior parietal cortex (PTLp). Co-activation of the VC and AC suppresses VC-induced PTLp responses, leaving AC-induced responses. Furthermore, parvalbumin-positive (PV+) interneurons in the PTLp mainly receive AC inputs, and muscimol inactivation of the PTLp or optogenetic inhibition of its PV+ neurons abolishes auditory dominance in the resolution of cross-modal sensory conflicts without affecting either sensory perception. Conversely, optogenetic activation of PV+ neurons in the PTLp enhances the auditory dominance. Thus, our results demonstrate that AC input-specific feedforward inhibition of VC inputs in the PTLp is responsible for the auditory dominance during cross-modal integration. |
