| First Author | Nguyen LT | Year | 2015 |
| Journal | Cancer Cell | Volume | 27 |
| Issue | 6 | Pages | 797-808 |
| PubMed ID | 26058078 | Mgi Jnum | J:222916 |
| Mgi Id | MGI:5646039 | Doi | 10.1016/j.ccell.2015.05.005 |
| Citation | Nguyen LT, et al. (2015) ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors. Cancer Cell 27(6):797-808 |
| abstractText | The significance of ERG in human prostate cancer is unclear because mouse prostate is resistant to ERG-mediated transformation. We determined that ERG activates the transcriptional program regulated by YAP1 of the Hippo signaling pathway and found that prostate-specific activation of either ERG or YAP1 in mice induces similar transcriptional changes and results in age-related prostate tumors. ERG binds to chromatin regions occupied by TEAD/YAP1 and transactivates Hippo target genes. In addition, in human luminal-type prostate cancer cells, ERG binds to the promoter of YAP1 and is necessary for YAP1 expression. These results provide direct genetic evidence of a causal role for ERG in prostate cancer and reveal a connection between ERG and the Hippo signaling pathway. |
