| First Author | Arboleda-Velasquez JF | Year | 2008 |
| Journal | Proc Natl Acad Sci U S A | Volume | 105 |
| Issue | 12 | Pages | 4856-61 |
| PubMed ID | 18347334 | Mgi Jnum | J:133358 |
| Mgi Id | MGI:3778327 | Doi | 10.1073/pnas.0709867105 |
| Citation | Arboleda-Velasquez JF, et al. (2008) Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A 105(12):4856-61 |
| abstractText | Vascular smooth muscle cells (SMCs) have been implicated in the pathophysiology of stroke, the third most common cause of death and the leading cause of long-term neurological disability in the world. However, there is little insight into the underlying cellular pathways that link SMC function to brain ischemia susceptibility. Using a hitherto uncharacterized knockout mouse model of Notch 3, a Notch signaling receptor paralogue highly expressed in vascular SMCs, we uncover a striking susceptibility to ischemic stroke upon challenge. Cellular and molecular analyses of vascular SMCs derived from these animals associate Notch 3 activity to the expression of specific gene targets, whereas genetic rescue experiments unambiguously link Notch 3 function in vessels to the ischemic phenotype. |
