| First Author | Arenkiel BR | Year | 2008 |
| Journal | Nat Methods | Volume | 5 |
| Issue | 4 | Pages | 299-302 |
| PubMed ID | 18327266 | Mgi Jnum | J:136582 |
| Mgi Id | MGI:3796579 | Doi | 10.1038/nmeth.1190 |
| Citation | Arenkiel BR, et al. (2008) Genetic control of neuronal activity in mice conditionally expressing TRPV1. Nat Methods 5(4):299-302 |
| abstractText | Here we describe a knock-in mouse model for Cre-loxP-based conditional expression of TRPV1 in central nervous system neurons. Expression of Cre recombinase using biolistics, lentivirus or genetic intercrosses triggered heterologous expression of TRPV1 in a cell-specific manner. Application of the TRPV1 ligand capsaicin induced strong inward currents, triggered action potentials and activated stereotyped behaviors, allowing cell type-specific chemical genetic control of neuronal activity in vitro and in vivo. |
